SIMULTANEOUS INJECTION OF PLASMA-DERIVED OR RECOMBINANT HEPATITIS-B VACCINES WITH YELLOW-FEVER AND KILLED POLIO VACCINES

Previous studies have shown an absence of interaction between hepatiti s B (HB) vaccine and other vaccines used in EPI programmes except for an apparent decrease of yellow fever antibody levels when hepatitis B and yellow fever vaccines are given simultaneously. We have therefore reinvestigated the interaction of these two vaccines and assessed the absence of interaction between inactivated polio vaccine and recombina nt or plasma-derived HB vaccine. The immune responses to polio vaccine injected simultaneously with plasma-derived or recombinant HB vaccine were observed to be equivalent and similar to those observed in the l iterature, In this randomized study, the immune responses to yellow fe ver vaccine injected simultaneously with plasma-derived or recombinant HB vaccine were comparable to those observed after separate administr ation of each vaccine, Moreover,no increase in adverse reactions was n oted.