A CHANGING PATTERN IN THE ASSOCIATION OF ORAL-CONTRACEPTIVES AND THE DIFFERENT GROUPS OF CONGENITAL LIMB DEFICIENCIES

A case-control study on different groups of isolated congenital limb d eficiency was performed in a ten-year population-based and revised Hun garian data set. A higher rate of one contraceptive gill type with rel atively high dose (ethynodiol diacetate 1.0 mg + ethinyloestradiol 0.0 5 mg) used in the periconceptional period was found in the mothers of cases with terminal transverse defect (adjusted relative odds 1.9 with 95% confidence interval of 1.1-3.4). This risk is minimised by the us e Of recent low-dose pills.