SYNTHESIS OF C-14-LABELED CEFLUPRENAM (E1077), A NOVEL PARENTERAL CEPHALOSPORIN ANTIBIOTIC

Cefluprenam (E1077) is a new parenteral cephalosporin with a well-bala nced antibacterial spectrum and potent activity. It was synthesized la belled in the side chain at the 3-position of the cephem with carbon-1 4, starting from potassium [C-14]cyanide, according to the method illu strated in Schemes 1,2. [C-14]Cefluprenam having a specific activity o f 3.9 MBq/mg, was obtained in 28.6 % overall radiochemical yield, with a radiochemical yield, with a radiochemical purity of more than 97.3 %.