INHIBITION BY ANTIDEPRESSANTS OF GLIBENCLAMIDE-SENSITIVE K-ENCLOSED XENOPUS OOCYTES( CURRENTS IN FOLLICLE)

Authors
SAKUTA H
Citation
H. Sakuta, INHIBITION BY ANTIDEPRESSANTS OF GLIBENCLAMIDE-SENSITIVE K-ENCLOSED XENOPUS OOCYTES( CURRENTS IN FOLLICLE), Canadian journal of physiology and pharmacology, 72(12), 1994, pp. 1586-1588
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Physiology
Journal title
Canadian journal of physiology and pharmacology → ACNP
ISSN journal
00084212
Volume
72
Issue
12
Year of publication
1994
Pages
1586 - 1588
Database
ISI
SICI code
0008-4212(1994)72:12<1586:IBAOGK>2.0.ZU;2-R
Abstract
Effects of antidepressive drugs on glibenclamide-sensitive K+ currents were investigated using follicle-enclosed Xenopus oocytes. Antidepres sive drugs, imipramine, desipramine, and amitriptyline, inhibited the K+ currents with IC50 (mu M) values of 35.4, 39.7, and 87.7, respectiv ely. The K+ current blocking actions of antidepressants appear to be a ssociated with their local anesthetic related structures.