Bt. Wang et al., CHORIONIC VILLI SAMPLING - LABORATORY EXPERIENCE WITH 4,000 CONSECUTIVE CASES, American journal of medical genetics, 53(4), 1994, pp. 307-316
Experience with 4,000 consecutive CVS cases shows that 1) the combinat
ion of both the direct and culture methods greatly reduces false diagn
oses and maternal cell contamination; 2) the time interval between the
sampling procedure and processing of villus specimens influences the
quality of direct preparations; 3) maternal cell contamination (MCC) c
an be minimized with dissection of CVS specimens. We have compiled a l
arge volume of confined placental mosaicism (CPM) cases to serve as a
resource in interpreting mosaic cytogenetic findings. It was noted tha
t, ip up to 92% of the mosaic cases, the abnormal cell line was confin
ed to the placenta. The frequency of true chromosomal mosaicism was 0.
2%, and is not different from that for amniocentesis. (C) 1994 Wiley-L
iss, Inc.