Using linear regression, the authors demonstrated a strong association
between State-specific coronary heart disease mortality rates and Sta
te prevalence of sedentary lifestyle (r2 = 0.34; P = 0.0002) that rema
ined significant after controlling for the prevalence of diagnosed hyp
ertension, smoking, and overweight among the State's population. This
ecologic analysis suggests that sedentary lifestyle may explain State
variation in coronary heart disease mortality and reinforces the need
to include physical activity promotion as a part of programs in the St
ates to prevent heart disease.