D. Uwanogho et al., EMBRYONIC EXPRESSION OF THE CHICKEN SOX2, SOX3 AND SOX11 GENES SUGGESTS AN INTERACTIVE ROLE IN NEURONAL DEVELOPMENT, Mechanisms of development, 49(1-2), 1995, pp. 23-36
Three chicken Sox (SRY-like box) genes have been identified that show
an interactive pattern of expression in the developing embryonic nervo
us system. cSox2 and cSox3 code for related proteins and both are pred
ominantly expressed in the immature neural epithelium of the entire CN
S of HK stage 10 to 34 embryos. cSox11 is related to cSox2 and cSox3 o
nly by virtue of containing an SRY-like HMG-box sequence but shows ext
ensive homology with Sox-4 at its C-terminus. cSox11 is expressed in t
he neural epithelium but is transiently upregulated in maturing neuron
s after they leave the neural epithelium. These patterns of expression
suggest that Sox genes play a role in neural development and that the
developmental programme from immature to mature neurons may involve s
witching of Sox gene expression. cSox11 also exhibits a lineage restri
cted pattern of expression in the peripheral nervous system.