DEMONSTRATION OF CARBOHYDRATE-SPECIFIC IMMUNOGLOBULIN G4 ANTIBODIES IN SERA OF PATIENTS RECEIVING GRASS-POLLEN IMMUNOTHERAPY

Authors
VANREE R AALBERSE RC
Citation
R. Vanree et Rc. Aalberse, DEMONSTRATION OF CARBOHYDRATE-SPECIFIC IMMUNOGLOBULIN G4 ANTIBODIES IN SERA OF PATIENTS RECEIVING GRASS-POLLEN IMMUNOTHERAPY, International archives of allergy and immunology, 106(2), 1995, pp. 146-148
Citations number
7
Categorie Soggetti
Allergy,Immunology
Journal title
International archives of allergy and immunology → ACNP
ISSN journal
10182438
Volume
106
Issue
2
Year of publication
1995
Pages
146 - 148
Database
ISI
SICI code
1018-2438(1995)106:2<146:DOCIGA>2.0.ZU;2-2
Abstract
From a group of 92 patients receiving grass pollen immunotherapy, and selected on grounds of high IgG(4) titers against Lol p I, sera were t ested for IgG(4) antibodies against the glycosylated grass pollen alle rgen Lol p XI. In 72 of 92 cases IgG(4) antibodies were demonstrated. The N-glycan of Lol p XI was earlier shown to be an epitope for IgE an tibodies. In the present study it was demonstrated that the carbohydra te structure is also recognized by IgG(4) antibodies, illustrating tha t IgG(4) responses are not immune-restricted to peptide epitopes, as w as suggested in several reports.