SYNTHETIC APPROACH TOWARD THE MINIMAL ACTIVE STRUCTURE OF PHOMOPSIN-USTILOXIN CLASS OF ANTIBIOTICS - CONSTRUCTION OF 13-MEMBERED CYCLIC PEPTIDE SKELETON

Authors
MUTOH R SHIRAI R KOISO Y IWASAKI S
Citation
R. Mutoh et al., SYNTHETIC APPROACH TOWARD THE MINIMAL ACTIVE STRUCTURE OF PHOMOPSIN-USTILOXIN CLASS OF ANTIBIOTICS - CONSTRUCTION OF 13-MEMBERED CYCLIC PEPTIDE SKELETON, Heterocycles, 41(1), 1995, pp. 9-12
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
41
Issue
1
Year of publication
1995
Pages
9 - 12
Database
ISI
SICI code
0385-5414(1995)41:1<9:SATTMA>2.0.ZU;2-2
Abstract
The 13-membered cyclic peptides (5a and 5b), the core structure of pho mopsin-ustiloxin crass of antibiotics, have been synthesized. The fina l macrolactamization was overcome by the intramolecular aminolysis of corresponding omega-amino pentafluorophenyl eater.