1',2',6'-THIADIAZINE 1',1'-DIOXIDE AND IMIDAZO [4',5'-C] [1',2',6']-THIADIAZINE 2',2'-DIOXODE-1,3-OXATHIOLANE NUCLEOSIDE ANALOGS - SYNTHESIS AND ANTI-HIV-1 ACTIVITY

Authors
BREINING T CIMPOIA AR MANSOUR TS CAMMACK N HOPEWELL P ASHMAN C
Citation
T. Breining et al., 1',2',6'-THIADIAZINE 1',1'-DIOXIDE AND IMIDAZO [4',5'-C] [1',2',6']-THIADIAZINE 2',2'-DIOXODE-1,3-OXATHIOLANE NUCLEOSIDE ANALOGS - SYNTHESIS AND ANTI-HIV-1 ACTIVITY, Heterocycles, 41(1), 1995, pp. 87-94
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
41
Issue
1
Year of publication
1995
Pages
87 - 94
Database
ISI
SICI code
0385-5414(1995)41:1<87:11AI[[>2.0.ZU;2-X
Abstract
A series of 1,3-oxathiolanes containing the 1,2,6-thiadiazine dioxide moieties were synthesized by various coupling conditions of the oxathi olane sugar (3) and silylated 1,2,6-thiadiazine dioxides (4-7) as base s. The compounds were evaluated for their potential anti-HIV activitie s in MT-4 cells and were found to lack activity at 100 mu g/ml.