A synthesis for the 1,7,10-anthyridine system by condensation of ethyl
-7-methyl-4-phenyl-1,8-naphthyridine-6-carboxylate (1) and DMFDMA, fo
llowed by ring closure with ammonium acetate is reported. The proposed
procedure allows the easy preparation of 7-substituted 1,7,10-anthyri
din-6-(7H)-ones (5) and 6-substituted 1,7,10-anthyridines (6) and (7).