THE REGULARITIES OF THE CHANGES OF AMINO-ACID PHYSICOCHEMICAL PROPERTIES WITHIN THE GENETIC-CODE

All the codons of the genetic code can be arranged into the closed one -step mutation ring, containing three periods of the same sequence of mutations (2,3,3,3,1,3,3,3,1,3,3,3,1,3,3,3,2,3,3,3). The codons of Gly play a role of the connecting element between the end of the third, a nd the beginning of the first period of the genetic code. The reactivi ty of amino acids, expressed by the reaction rates of aminolysis react ion of N-hydroxysuccinimide esters of protected amino acids with p-ani sidine, changes periodically with the respect to the mutation periods of the genetic code. Chou-Fasman P-alpha as well as P-beta conformatio nal parameters of amino acids, and also the compositional frequencies of amino acids in proteins, demonstrate the pseudosymmetry pattern wit h respect to the center of one-step mutation ring, which is situated b etween Thr ACY and ACR codons.