ASSIGNMENT OF ABSOLUTE-CONFIGURATION TO AN IMPROVED ENANTIOSELECTIVE NAPROXEN SELECTOR

Assignment of absolute configuration to a recently developed chiral se lector useful in the separation of the underivatized enantiomers of na proxen and other nonsteroidal anti-inflammatory drugs (NSAIDs) is desc ribed, Circular dichroism, H-1 NMR, and X-ray diffraction have been us ed to confirm the original assignment which was based solely upon elut ion orders from HPLC chiral stationary phases. All of these techniques agree in the assignment of the (S,S) absolute configuration to the en antiomer of the chiral selector which associates preferentially with ( S)-naproxen. (C) 1994 Wiley-Liss, Inc.