DIRECT DETERMINATION OF THE ENANTIOMERIC PURITY OF (R)-2-HYDROXY-4-PHENYLBUTYRIC AND (S)-2-HYDROXY-4-PHENYLBUTYRIC ACID

Authors
CHILMONCZYK Z KSYCINSKA H KRUSZEWSKA H CYBULSKI J
Citation
Z. Chilmonczyk et al., DIRECT DETERMINATION OF THE ENANTIOMERIC PURITY OF (R)-2-HYDROXY-4-PHENYLBUTYRIC AND (S)-2-HYDROXY-4-PHENYLBUTYRIC ACID, Chirality, 6(8), 1994, pp. 627-630
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
6
Issue
8
Year of publication
1994
Pages
627 - 630
Database
ISI
SICI code
0899-0042(1994)6:8<627:DDOTEP>2.0.ZU;2-I
Abstract
The determination of enantiomeric purity of (R)- and (S)-2-hydroxy-4-p henylbutyric acid by chiral HPLC is described. Good resolution has bee n obtained on covalently bonded L-hydroxyproline saturated with Cu(II) ions. The method makes possible the determination of enantiomeric pur ity in media containing growing cells. (C) 1994 Wiley-Liss, Inc.