HISTOLOGICAL STUDIES ON THE RHEUMATOID SYNOVIAL-MEMBRANE IRRADIATED WITH A LOW-ENERGY LASER

The beneficial effects of low energy laser irradiation on rheumatoid a rthritis (RA) joints have been reported, but the mechanisms of action of low energy lasers in RA are unclear. The synovial membrane in cases of RA was studied histologically to observe the effects of low energy laser irradiation. Fourteen knee joints of RA cases, which had been s cheduled for arthroplasty, were irradiated with a gallium-aluminium-ar senide (Ga-Al-As) laser (790 nm in wavelength and 10 mW of output powe r) prior to the surgical operation, at six points of the external aspe ct of the knee joint for 80 seconds at each points once a day for 6 da ys. On the day following the last irradiation, pieces of synovial memb rane from the lateral irradiated area and from the median nonirradiate d area as a control were resected during the arthroplasty. The histolo gical findings of the irradiated synovial membrane showed flattening o f epithelial cells, decreased villous proliferation, narrowed vascular lumen, and less infiltration of inflammatory cells compared with thos e of nonirradiated synovia. The evaluation of slides was done in a bli nded manner, and significant differences was seen by Wilcoxon's t-test (P < 0.01). Histological findings suggested that the low energy laser irradiation induced suppression of inflammation in the synovial membr ane of RA. (C) 1994 Wiley-Liss, Inc.