ANTIPROTOZOAL ACTIVITIES OF CENTIPEDA-MINIMA

In vitro activity against Giardia intestinalis was used for bioassay-g uided fractionation of crude extracts from C. minima. The sesquiterpen e lactone, brevilin A was isolated and found to have antigiardial acti vity (IC50 = 16.1 mu M) and was similarly active in vitro against Enta moeba histolytica (IC50 between 4.5 and 9 mu M) and against Plasmodium falciparum (IC50 = 9.42 mu M). Three flavonoids, quercetin, quercetin 3-methyl ether and kaempferol 7-glucosylrhamnoside were also isolated .