In order to check the possibility of labeling sub-libraries, we synthe
sized a colored support by acylation of aminomethyl resin with a speci
al Boc-amino acid (a red azo dye). Syntheses of model peptides proved
that the colored resin is suitable for solid phase peptide synthesis.
Color labeling was also made by coupling resin-bound peptides at their
N-termini with a blue dye. Colored resins as well as labeling at the
N-terminus offer a possibility to simplify the preparation of support-
bound peptide sub-library kits and their use in sequence determination
of bioactive peptides. (C) 1994 Wiley-Liss, Inc.