GENE POOL OF INHABITANTS OF SOUTH-EASTERN EURASIA IN THE LIGHT OF DATA ON POLYMORPHISM OF MITOCHONDRIAL-DNA - NEW DATA ON THE POLYMORPHISM OF RESTRICTION SITES IN THE D-LOOP OF MTDNA IN THE NATIVE POPULATION OF THE CAUCASUS AND SIBERIA

New data about eleven polymorphic sites of restriction in the D-loop o f mtDNA revealed with the Ava II, BamH I, EcoR V, Hae III, Kpn I, Rsa I, and Sau3A I restriction enzymes in native populations of the Caucas us (N = 40) and Siberia (N = 44) are presented. A comparison of these groups with each other and with common data for western and eastern Eu rope as well as for central and eastern Asia reveals a large similarit y of all the population groups of Eurasia in respect to the frequency of each polymorphic site separately. The interpopulation differentiati on of frequency of polymorphic restriction sites in Eurasia is low and identical at such different hierarchical levels of population structu re as ethnic group and extended regional population group. An analysis of differences between sites in the frequency of the presence of rest riction sites for BamH I, EcoR V, Hae III, and Sau3A I and the absence of sites for Ava II, Kpn I, and Rsa I at definite loci of the nucleot ide chain allowed determination of the region of equilibrium between d irect, site-generating, and reverse mutations to be 0.43 q. Among elev en polymorphic restriction sites analyzed here, only polymorphism in t he Hae III site at the position 16 517 in the population of Eurasia wa s characterized with frequencies close to equilibrium that determined the extremely large evolutionary age of this polymorphism.