Preferential recruitment of new blood donors from subpopulations with
low rates of transfusion-transmitted diseases (TTDs) is being evaluate
d as a preventive, prosocial, nonstigmatizing innovation for increasin
g the safety of the blood supply. Identification of lower risk subpopu
lations, selected for intensified recruitment, is ''epidemiologically
informed'' through analyses of public domain surveillance data for AID
S and other TTDs. The efficacy of this epidemiologic approach is illus
trated with analyses for Miami. Culturally competent behavioral recrui
tment strategies targeted for identified lower risk subpopulations wil
l be implemented. Recruitment of lower risk donors is contrasted with
approaches that ban high-risk populations from blood donation.