MULTISTATE MODELING OF LIVER-TRANSPLANTATION DATA

This paper concerns the survival analysis of liver transplant patients when patients with a potentially fatal rejection of the transplanted organ may receive a retransplant, A multistate model, analysing the st ates 'alive with first graft' and 'alive with second graft' separately , is suggested. Proportional hazards models and logistic regression mo dels are used to evaluate which risk factors related to donor, preserv ation and recipient, influence the transition intensities. The complet e model is used to predict overall survival of a patient and to study the influence of the risk factors on total survival.