PLATINUM(II) COMPLEXES WITH PORPHYRIN LIG ANDS - SYNTHESIS AND SYNERGISMS IN THE PHOTODYNAMIC TUMOR-THERAPY

Twelve porphyrin ligands (2-5, 8, 13-16, 19, 27, 28) and their platinu m(II) complexes (29-40) were synthesized and characterized. Nine of th e porphyrins are derived from hemin, and three are based on tetrapheny lporphyrin. The Ligands were transformed into diammine-dicarboxylatopl atinum(II) complexes and diamine-dichloroplatinum(II) complexes. The a ntitumor activity in the photodynamic therapy of the Ligands and their complexes was tested in vitro towards the MDA-MB-231 mammary carcinom a cell line. The results obtained showed an additive effect of the pho todynamic activity of the porphyrin skeleton when irradiated with visi ble red light and the cytotoxic activity of the platinum moiety in the complexes.