B. Decollongue et al., COMPARATIVE-STUDY OF DIFFERENT PREDICTIVE METHODS OF PEPTIDES RETENTION TIME ON CHROMATOGRAPHIC REVERSED-PHASE COLUMNS, Journal of liquid chromatography, 17(20), 1994, pp. 4349-4364
Two peptides samples were studied in order to compare the validity of
some predictive retention times. We examined the predictive retention
times stated by Guo and based on the relative hydrophobic contribution
of each amino acid residue, by Mant who takes into account the length
of the peptides and by Chabanet who discriminates three groups of ami
no acids. Although Chabanet's model provided good results, we found th
at a more general correlation was obtained with Mant's retention predi
ction especially in the case of peptides containing a high fraction of
basic residues.