TRF1, A MAMMALIAN TELOMERIC PROTEIN

Telomerase adds TTAGGG repeats onto mammalian chromosome ends, repleni shing the terminal sequence loss incurred during DNA replication This maintenance of telomeric DNA preserves binding sites for telomeric pro teins, which form a protective nucleoprotein complex at chromosome end s. The recent isolation of TRF1, the mammalian telomeric-repeat bindin g factor, should now allow the structure and function of the telomeric complex to be examined in detail.