Citation
H. Parnes et Gt. Huang, SYNTHESIS OF THE ANTIINFLAMMATORY PRODRUG RS-42169-C-14, Journal of labelled compounds & radiopharmaceuticals, 36(1), 1995, pp. 51-56
Citations number
10
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
ISSN journal
03624803
Volume
36
Issue
1
Year of publication
1995
Pages
51 - 56
Database
ISI
SICI code
0362-4803(1995)36:1<51:SOTAPR>2.0.ZU;2-O
Abstract
A facile synthesis of the antiinflammatory agent RS-42169-C-14, based
on a carbonation/cycloaddition sequence is described. The product was
obtained in 36% yield from (BaCO3)-C-14 at a specific activity of 52 m
Ci/mmole. The design of the six step sequence was such that pure inter
mediates were isolated by extractive workup, and only a single chromat
ographic purification was required.