SYNTHESIS OF PLATINUM-195M RADIOLABELED DIAMMINE(1,1-CYCLOBUTANEDICARBOXYLATO)PLATINUM(II) OF HIGH RADIONUCLIDE PURITY

Authors
KAWAI K TANAKA Y NAKANO Y EHRLICH W AKABOSHI M
Citation
K. Kawai et al., SYNTHESIS OF PLATINUM-195M RADIOLABELED DIAMMINE(1,1-CYCLOBUTANEDICARBOXYLATO)PLATINUM(II) OF HIGH RADIONUCLIDE PURITY, Journal of labelled compounds & radiopharmaceuticals, 36(1), 1995, pp. 65-71
Citations number
16
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
36
Issue
1
Year of publication
1995
Pages
65 - 71
Database
ISI
SICI code
0362-4803(1995)36:1<65:SOPRD>2.0.ZU;2-E
Abstract
An experimental method is described for the synthesis of Pt-195m-radio labeled clobutanedicarboxylatio)platinum(II)(carboplatin). 10 mg of 95 % enriched (PT)-P-194 was irradiated for 75 h in the hydraulic convey er of KUR at a thermal neutron flux of approx.8.15x10(13) n.cm(-2).sec (-1), and the Pt-195m-radiolabeled carboplatin was synthesized and pur ified using HPLC (column: C-18-ODS). The chemical yield was higher tha n 59.1 %, its chemical purity was greater than 99.3 %, the radionuclid ic purity was nearly 100 % and the specific activity was 6.0 MBq.mg(-1 ) carboplatin.