SYNTHESIS OF HIGH SPECIFIC ACTIVITY [15,16-H-3(2)]BUPRENORPHINE

Authors
OTVOS F HOSZTAFI S SIMON C TOTH G
Citation
F. Otvos et al., SYNTHESIS OF HIGH SPECIFIC ACTIVITY [15,16-H-3(2)]BUPRENORPHINE, Journal of labelled compounds & radiopharmaceuticals, 36(1), 1995, pp. 79-83
Citations number
17
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
36
Issue
1
Year of publication
1995
Pages
79 - 83
Database
ISI
SICI code
0362-4803(1995)36:1<79:SOHSA[>2.0.ZU;2-R
Abstract
Tritium labelling of buprenorphine, a mixed agonist-antagonist opioid ligand, was performed with a specific activity of 2.35 TBq/mmol (63.6 Ci/mmol) starting with 15,16-didehydrobuprenorphine. Labels at positio ns 15 and 16 of the morphine skeleton proved to be sufficiently stable under strong acidic or basic conditions.