CONVENIENT SYNTHESIS OF [2-C-14]-METHYLGLYOXAL BIS(GUANYLHYDRAZONE), [C-14] MITOGUAZONE

[2-C-14]-Methylglyoxal bis(guanylhydrazone) dihydrochloride, [C-14]-mi toguazone, 3, has been prepared in three steps from potassium [1-C-14] -acetate in an overall radiochemical yield of 16%. The key steps in th is procedure are the formation of the sodium Salt of [acetone-2-C-14]- methylsulfinylacetone, 5, and Pummerer rearrangement to the [C-14] lab elled hemithioacetal, 6, which is trapped with two equivalents of amin oguanidine to afford the desired [C-14]-mitoguazone, 3.