LACK OF A SPECIFIC EFFECT OF CORTICOTROPIN-RELEASING HORMONE (CRH) ONPLASMA-LEVELS OF 13,14-DIHYDRO-15-KETO-PROSTAGLANDIN E(2) IN NORMAL SUBJECTS

Authors
ZACHARIEVA S MUCHA I WIPPERMANN M SHEITANOVA S ANDONOVA K
Citation
S. Zacharieva et al., LACK OF A SPECIFIC EFFECT OF CORTICOTROPIN-RELEASING HORMONE (CRH) ONPLASMA-LEVELS OF 13,14-DIHYDRO-15-KETO-PROSTAGLANDIN E(2) IN NORMAL SUBJECTS, Prostaglandins, leukotrienes and essential fatty acids, 52(1), 1995, pp. 55-57
Citations number
13
Categorie Soggetti
Endocrynology & Metabolism",Biology
Journal title
Prostaglandins, leukotrienes and essential fatty acids → ACNP
ISSN journal
09523278
Volume
52
Issue
1
Year of publication
1995
Pages
55 - 57
Database
ISI
SICI code
0952-3278(1995)52:1<55:LOASEO>2.0.ZU;2-G
Abstract
The responses of plasma adrenocorticotrophic hormone (corticotrophin, ACTH), cortisol and 13,14-dihydro-15-keto-prostaglandin E(2) (PGE(2)-M ), a stable metabolite of prostaglandin E(2) (PGE(2)) to i.v. injectio n of corticotrophin-releasing hormone (CRH) were studied in eight heal thy subjects before and after a dexamethasone suppression test. We dem onstrated a slight increase in PGE(2)-M after CRH injection in a dose that markedly augmented ACTH and cortisol levels, CRH did not produce any significant changes in ACTH, cortisol or PGE(2)-M after dexamethas one treatment, The results did not confirm a specific effect of CRH on PGE(2) production.