Tma. Elattar et Hs. Lin, VITAMIN-E SUCCINATE POTENTIATES THE INHIBITORY EFFECT OF PROSTAGLANDINS ON ORAL SQUAMOUS CARCINOMA CELL-PROLIFERATION, Prostaglandins, leukotrienes and essential fatty acids, 52(1), 1995, pp. 69-73
Previous studies have shown that prostaglandin E(2) (PGE(2)) and vitam
in E succinate can act in an additive manner to inhibit the proliferat
ion of human oral squamous carcinoma cells (SCC-25), The initial studi
es on the additive anticancer activity of PGE(2) and vitamin E succina
te have been extended to include antineoplastic PGs, Delta(12)-PGJ(2)
and PGJ(2). Treatment of oral squamous carcinoma cells (SCC-15) with D
elta(12)-PGJ(2), PGJ(2), and vitamin E succinate, individually, caused
significant concentration-dependent inhibition of cell proliferation
to various degrees, PGJ(2) was most potent and caused an inhibition th
at corresponded to 85.55% at 10(-5) M. Addition of 1 mu M of vitamin E
succinate to Delta(12)-PGJ(2) or PGJ(2) resulted in a significant inc
rease in the inhibitory potency of the lower concentrations of the two
PGs. These results suggest a novel role for a mixture of PGs and vita
min E as potent antitumor proliferative agents.