INHIBITION BY NIFEDIPINE OF THE EFFLUX OF PLASMA LOW-DENSITY-LIPOPROTEIN AND ALBUMIN FROM THE VASCULATURE OF THE MOUSE MESENTERY IN-VIVO

Efflux and extravascular accumulation of intravenously administered fl uorescent-labeled low-density lipoprotein (LDL) and albumin were measu red in superfused mouse mesenteric preparation in anesthetized mice. P retreatment of animals with nifedipine (1 and 3 mg/kg sc) significantl y reduced both the extravascular accumulation of LDL (measured by fluo rescence densitometry) and the efflux (measurement of the tracers in t he superfusate) of both LDL and albumin. These effects may help to exp lain the possible anti-atherogenic effect of nifedipine. (C) 1995 Acad emic Press, Inc.