Bj. Dickson et al., CONTROL OF DROSOPHILA PHOTORECEPTOR CELL FATES BY PHYLLOPOD, A NOVEL NUCLEAR-PROTEIN ACTING DOWNSTREAM OF THE RAF KINASE, Cell, 80(3), 1995, pp. 453-462
The phyllopod (phyl) gene regulates the fates of a subset of cells in
the developing Drosophila eye; in the absence of phyl function, the R1
, R6, and R7 photoreceptors are transformed into additional cone cells
, whereas ectopic phyl expression in the cone cell precursors transfor
ms these cells into additional R7 cells. Within this group of cells, p
hyl expression thus mimics activation of the Raf pathway in its abilit
y to induce photoreceptor rather than cone cell development. Furthermo
re, the transformation of cone cells into R7 cells in response to Raf
activation is both accompanied by and dependent upon ectopic phyl expr
ession. phyl thus represents a possible target gene of the Raf pathway
during eye development, controlling the fates of a novel subset of ph
otoreceptors.