A 67-year-old man with a history of an attack of pancreatitis was repe
atedly investigated for recurrent gastrointestinal bleeding necessitat
ing blood transfusions. Routine investigations did not reveal the sour
ce of bleeding, Repeated angiograms also were not diagnostic. A hot sp
ot identified on a Tc-99m-pertechnate-labelled erythrocyte scan prompt
ed an endoscopic retrograde cholangio-pancreatography (ERCP), which sh
owed bleeding through the papilla of Vater. The source of bleeding app
eared to be a small pancreatic pseudocyst. The patient was treated wit
h a duodenopancreatectomy in which the pylorus was preserved. No reble
eding occurred since the operation. Pancreatic pseudocysts must be con
sidered as a source of upper gastrointestinal bleeding in patients wit
h bleeding of ''obscure'' origin. Tc-99m-pertechnate-labelled erythroc
yte scanning and ERCP may be helpful, even when angiography is normal.