(R)-2,3-O-CYCLOHEXYLIDENEGLYCERALDEHYDE, A VERSATILE INTERMEDIATE FORASYMMETRIC-SYNTHESIS OF CHIRAL ALCOHOL

Authors
CHATTOPADHYAY A MAMDAPUR VR
Citation
A. Chattopadhyay et Vr. Mamdapur, (R)-2,3-O-CYCLOHEXYLIDENEGLYCERALDEHYDE, A VERSATILE INTERMEDIATE FORASYMMETRIC-SYNTHESIS OF CHIRAL ALCOHOL, Journal of organic chemistry, 60(3), 1995, pp. 585-587
Citations number
43
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
60
Issue
3
Year of publication
1995
Pages
585 - 587
Database
ISI
SICI code
0022-3263(1995)60:3<585:(AVIF>2.0.ZU;2-S
Abstract
Grignard addition to (R)-2,3-O-cyclohexylideneglyceraldehyde (IIa) gav e rise to column chromatographically separable diastereo alcohols 2 an d 3 including highly functionalized and synthetically exploitable homo allylic alcohols 2e and 3e and homopropargylic alcohols 2f and 3f. Com pound 3c on functional manipulation gave rise to (-)-coriolic acid syn thon 6.