Travellers returning from the tropics frequently consult a physician e
ven if they have no actual symptoms. Physical check-ups in asymptomati
c returnees rarely detect dangerous conditions. The most common labora
tory finding is intestinal parasites. Blood eosinophilia may indicate
helminthic infections, such as strongyloidosis, filariosis, schistosom
iasis and others. If there are no diagnostically suggestive symptoms a
systematic, step-by-step workup is recommended (stool parasitology, s
erology, and special methods to demonstrate parasites in blood or tiss
ues). The most common symptom of returnees from the tropics is diarrhe
a, or other disorders of intestinal motility. Appropriate investigatio
ns include parasitological and bacteriological tests, and - if the cou
rse is more chronic - endoscopy. If diarrhea is associated with fever,
systemic infections (e.g. falciparum malaria) must be considered. Fev
er as a leading sign may mask a number of potentially dangerous infect
ions. If there are no other obvious signs or symptoms indicating a par
ticular etiology, the diagnostic approach should consider first of all
those systemic infections, which are potentially life-threatening and
can be cured by specific therapy, i.e. bacterial meningitis, falcipar
um malaria, septicemia (including typhoid fever), extraintestinal ameb
iasis, and African trypanosomiasis.