REFRACTORY-ANEMIA WITH EXCESS OF BLASTS IN TRANSFORMATION TERMINATINGAS PH NEGATIVE CHRONIC MYELOID-LEUKEMIA

A pertinent leukaemia with refractory anemia excess blasts in transfor mations terminating as Ph negative chronic myeloid (CML) is described. It is believed that the initial picuture of RABBET as well as the ter minating picture of CML was caused by the same abnormal clone. Myelody splastic syndromes are among the most frequent haematological malignan cies, particularly in the elderly. The MSD are characterized by ineffe ctive hematopoiesis peripheral blood cytopenias and hypercellular or a narchic bone marrow. There are qualitative and quantitative abnormalit ies affecting all cell lines. (1) According to Fab classification, the re are five types of MSD which include: 1) refractory anemia (RA), 2) RA with ringed sideroblasts (RARS), 3) Refractory anemia with excess o f blasts (RAEB), 4) RAEB in transformation (RAEBt) and 5) Chronic Myel omonocytic Leukaemia (CMML). Refractory anaemia is probably the common est subtype of MDS(S). Median survival for patients with MDS ranges fr om four years for RAS to three year for RAEBt. We describe a patient w ith RAEBt Type of MDS who developed picture like CML after a period of two years.