IMPROVEMENT OF ORTHOGRADE GOLYTELY COLON LAVAGE BY ADDITIONAL APPLICATION OF SIMETHICONE

The effectiveness of an additional application of Simethicone during a n orthograde lavage with Golytely solution in preparation for colonsco py was tested in a prospective, randomized, placebo-controlled double blind study on 152 patients 78 Simethicone, 74 placebo). The colon reg ions were separated into rectosigmoid, descending colon, transverse co lon and ascending colon and interpreted according to the criteria form ation of foam and contamination with feces. By the endoscopic examinat ion of the colon we found a statistically significant improvement in v isibility in the patients treated with Simethicone in contrast to plac ebo both in the individual scores, separated according to each of the colon re-gions, and in the total scores (p < 0,01). Furthermore, the t ime needed for the colonscopy could be significantly shortened in the Simethicone group (p < 0,05). Adverse effects were not observed. We co nclude that the additional application of Simethicone during the ortho grade colon ravage with Golytely solution results in an improvement in the preparation for the colonoscopy as well as visibility of the colo n mucosa.