STUDY OF THE POSSIBLE ASSOCIATION OF HLA CLASS-II, CD4, AND CD3 POLYMORPHISMS WITH SCHIZOPHRENIA

In the present study the HLA-DRB and DPB1 alleles as well as CD4 and C D3 polymorphisms were tested in 100 Belgian schizophrenic patients and 204 controls. Our results indicate a significant negative association of the DPB10101 allele with schizophrenia (relative risk [RR] = 0.27 ). Furthermore a significant positive and negative association could b e noticed for the CD4A4 allele and CD4*A7/A8 genotype, respectively ( RR 1.79 and 0.47, respectively), These findings suggest that some cont ribution of HLA class II and CD4 genes to an autoimmune-like pathogene sis in schizophrenia might exist. (C) 1994 Wiley-Liss,Inc.