EXPRESSION OF OSTEOPONTIN MESSENGER-RNA IN THE RAT-KIDNEY ON EXPERIMENTAL-MODEL OF RENAL STONE

We investigated the expression of osteopontin (OPN) messenger (m) RNA in the rat kidney under the experimental models of several conditions that are considered to be risk factors of human renal stones. In the r enal stone formation model administrated glyoxylic acid and 1,25-dihyd roxyvitamin D-3, pyelonephritis model and hydronephrosis model the exp ression of OPN mRNA in the distal convoluted tubule of the kidney was enhanced compared with the control which was sporadically positive ult ilizing in situ hybridization and northern blot analysis. The expressi on of OPN mRNA was markedly inhibited in the renal stone formation mod el by concominant administration of estradiol and/or progesterone.