EFFICIENT ONE-POT CONVERSION OF 6-METHYL-2-NITROANILINE INTO 1-ALKYLOXY-2-ALKYL-4-METHYL, 1-BENZYLOXY-2-PHENYL-4-METHYL, AND 1-ALLYLOXY-4-METHYL-2-VINYL-BENZIMIDAZOLE

Authors
GARDINER JM LOYNS CR
Citation
Jm. Gardiner et Cr. Loyns, EFFICIENT ONE-POT CONVERSION OF 6-METHYL-2-NITROANILINE INTO 1-ALKYLOXY-2-ALKYL-4-METHYL, 1-BENZYLOXY-2-PHENYL-4-METHYL, AND 1-ALLYLOXY-4-METHYL-2-VINYL-BENZIMIDAZOLE, Synthetic communications, 25(6), 1995, pp. 819-827
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
25
Issue
6
Year of publication
1995
Pages
819 - 827
Database
ISI
SICI code
0039-7911(1995)25:6<819:EOCO6I>2.0.ZU;2-F
Abstract
6-Methyl-2-nitroaniline reacts with alkyl, benzyl and allyl halides an d NaH as base, to afford 1-alkoxy-2-alkyl-, 1-benzyloxy-2-aryl- and 1- allyloxy-2-vinyl-benzimidazoles in good to excellent yields (73-98%), via a novel one-pot N-alkylation-heterocyclization-O-alkylation sequen ce.