SYNTHESIS OF N-SUBSTITUTED 7-BETA-DIPRENORPHINE DERIVATIVES

Authors
MARTON J MIKLOS S HOSZTAFI S MAKLEIT S
Citation
J. Marton et al., SYNTHESIS OF N-SUBSTITUTED 7-BETA-DIPRENORPHINE DERIVATIVES, Synthetic communications, 25(6), 1995, pp. 829-848
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
25
Issue
6
Year of publication
1995
Pages
829 - 848
Database
ISI
SICI code
0039-7911(1995)25:6<829:SON7D>2.0.ZU;2-K
Abstract
The separation of thevinone (2a) and beta-thevinone (2b), as well as t hat of dihydrothevinone (3a) and beta-dihydrothevinone (3b) was accomp lished. By the application of various procedures numerous new N-substi tuted Diprenorphine analogues (8a-f) with 7R absolute configuration we re synthesized. Detailed pharmacological investigation of the prepared compounds may contribute to a better understanding of the structure-a ctivity relationship of morphine alkaloids.