PROTECTION OF HAMSTERS AGAINST EXPERIMENTAL MUMPS-VIRUS (MUV) INFECTION BY ANTIBODIES RAISED AGAINST THE MUV SURFACE GLYCOPROTEINS EXPRESSED FROM RECOMBINANT VACCINIA VIRUS VECTORS

Authors
HOUARD S VARSANYI TM MILICAN F NORRBY E BOLLEN A
Citation
S. Houard et al., PROTECTION OF HAMSTERS AGAINST EXPERIMENTAL MUMPS-VIRUS (MUV) INFECTION BY ANTIBODIES RAISED AGAINST THE MUV SURFACE GLYCOPROTEINS EXPRESSED FROM RECOMBINANT VACCINIA VIRUS VECTORS, Journal of General Virology, 76, 1995, pp. 421-423
Citations number
16
Categorie Soggetti
Virology,"Biothechnology & Applied Migrobiology
Journal title
Journal of General Virology → ACNP
ISSN journal
00221317
Volume
76
Year of publication
1995
Part
2
Pages
421 - 423
Database
ISI
SICI code
0022-1317(1995)76:<421:POHAEM>2.0.ZU;2-H
Abstract
The fusion (F) and haemagglutinin-neuraminidase (HN) glycoproteins of mumps virus (MuV) have been produced in CV1 cells via vaccinia virus r ecombinants. Recombinant proteins accumulated in infected cells and we re glycosylated. Upon reduction, the F protein product was completely converted into its subunits. Hamsters infected with vaccinia recombina nts expressing either the F or HN proteins produced antibodies recogni zing MuV antigens and neutralizing MuV infectivity in vitro. These ant ibodies provided protection against MuV-induced encephalitis in newbor n hamsters.