EFFECT OF DERIVATIVES OF 2-THIOHYDANTOIN-3-ACETIC ACID ON GLUTATHIONE(GSH) CONTENT IN SELECTED ORGANS OF MICE

Authors
DZIUBEK K KOROHODA MJ RYCZEK J
Citation
K. Dziubek et al., EFFECT OF DERIVATIVES OF 2-THIOHYDANTOIN-3-ACETIC ACID ON GLUTATHIONE(GSH) CONTENT IN SELECTED ORGANS OF MICE, Acta Biologica Cracoviensia. Series Zoologia, 36, 1994, pp. 1-12
Citations number
NO
Categorie Soggetti
Zoology
Journal title
Acta Biologica Cracoviensia. Series Zoologia → ACNP
ISSN journal
0001530X
Volume
36
Year of publication
1994
Pages
1 - 12
Database
ISI
SICI code
0001-530X(1994)36:<1:EODO2A>2.0.ZU;2-G
Abstract
The effect of some derivatives of 2-thiohydantoin-3-acetic acid on the concentration of GSH in the blood, brain, liver, and kidneys was exam ined. GSH content was determined by the technique of Ellman. In most c ase administration of both 30 mg/kg and 60 mg/kg doses decreased the c oncentration of GSH in the blood, brain and kidneys. The results obtai ned suggest that the administrated derivatives of 2-thiohydantoin-3-ac etic acid are not inductors of the synthesis of GSH in the brain, bloo d and kidneys.