NEPHROTIC SYNDROME AND ADJUVANT TREATMENT WITH TAMOXIFEN FOR EARLY BREAST-CANCER CASE-REPORT AND REVIEW OF THE LITERATURE

A 56 year old postmenopausal patient underwent a right radical mastect omy for a stage I breast cancer. An adjuvant treatment with tamoxifen was planned, but, because of patient's choice, a regular administratio n of the endocrine treatment started only one year after the operation . After a very short period of drug administration, she developed a st eroid responsive nephrotic syndrome. We have reviewed the internationa l literature concerning drug-induced renal disease; this is the first case of a tamoxifen-induced nephrotic syndrome.