TAMOXIFEN OR SURGERY PINS TAMOXIFEN AS PRIMARY-TREATMENT FOR ELDERLY PATIENTS WITH OPERABLE BREAST-CANCER - THE GRETA TRIAL

A multicentre trial in operable breast cancer in patients aged over 70 years compared tamoxifen alone (starting with a loading dose of 160 m g on the first day) with surgery pills adjuvant tamoxifen. 473 patient s were recruited with a median follow up of 36 months. Local progressi on occurred in 15/237 patients in the surgical arm versus 60/236 in th e tamoxifen alone arm (p= 0.000). There were 48 deaths in the surgical arma and 41 in the other one (p= 0.67). Distant metastases occurred i n 33/237 patients in the surgical arm versus 19/236 in the tamoxifen a lone arm (p= 0.058). In elderly patients with operable breast cancer s urgery is indicated. Tamoxifen alone is an adequate alternative in fra il patients. A loading dose of Tamoxifen may be useful in preventing t he expression of the metastatizing phenotype. In any case, delayed sur gery does not prejudice the overall survival.