In primary pelviureteric junction obstruction with a large pelvicalice
al system, urine flow is impaired not only by intrinsic obstruction, b
ut also by ineffective pressure development (Laplace's principle) and
perhaps by vessels or fibrous bands. As endopyelotomy only corrects th
e intrinsic factor, we examined the effect of pelvicaliceal size on th
e results of endopyelotomy. In a prospective study, 35 patients with p
rimary pelviureteric junction obstruction were treated by endopyelotom
y. The volume of the pelvicaliceal system was estimated preoperatively
and correlated with the outcome. After endopyelotomy, all patients we
re stented with a ureteric catheter for 6 weeks. At 6 weeks 27/35 pati
ents (77%) had free drainage of urine into the bladder. Of patients wi
th pelvicaliceal volumes of 10-40 ml and 41-65 ml, 17 of 18 (94%) had
a successful result, whereas in patients with pelvicaliceal volumes of
66-90 mi and those greater than 90 ml, only 10 of 17 (59%) were succe
ssful. This difference in success rate associated with pelvicaliceal v
olume was statistically significant (p = 0.018). After 6 months follow
-up there were no relapses. Endopyelotomy is a safe and successful tec
hnique, but large preoperative pelvicaliceal volume is associated with
a reduced success rate.