EFFECT OF ARGININE ON GROWTH OF SQUAMOUS-CELL CARCINOMA IN THE C3H KMMOUSE/

Authors
Citation
Je. Hester et We. Fee, EFFECT OF ARGININE ON GROWTH OF SQUAMOUS-CELL CARCINOMA IN THE C3H KMMOUSE/, Archives of otolaryngology, head & neck surgery, 121(2), 1995, pp. 193-196
Citations number
21
Categorie Soggetti
Otorhinolaryngology,Surgery
ISSN journal
08864470
Volume
121
Issue
2
Year of publication
1995
Pages
193 - 196
Database
ISI
SICI code
0886-4470(1995)121:2<193:EOAOGO>2.0.ZU;2-Z
Abstract
Objective: To determine whether arginine supplementation affects tumor growth or metastases in well-fed and starved mice using a squamous ce ll carcinoma VII tumor model. Design: Prospective study in a murine mo del. Interventions: Simulation of the cachectic state often seen in pa tients with head and neck cancer, induction of squamous cell carcinoma , and administration of standard and arginine-supplemented diet. Main Outcome Measures: Effect of arginine supple-mentation on tumor growth, metastases, and host weight gain. Results: Tumor weight was significa ntly decreased in those animals receiving 5% arginine supplementation. The rate of metastases was lower in animals receiving arginine, but t his difference did not reach statistical significance. All groups rece iving supplemental arginine experienced weight loss, which contradicts the findings that arginine as an anabolic agent may not be present in cancer bearing hosts.