J. Hotz et al., PANTOPRAZOLE IS SUPERIOR TO RANITIDINE IN THE TREATMENT OF ACUTE GASTRIC-ULCER, Scandinavian journal of gastroenterology, 30(2), 1995, pp. 111-115
Background: Pantoprazole is a newly developed gastric H+/K+-adenosine
triphosphatase inhibitor with a potent and long-acting inhibitory effe
ct on gastric acid secretion. Methods: In a double-blind multicenter s
tudy with 28 centers in Germany, pantoprazole (40 mg before breakfast)
was compared with ranitidine (300 mg at bedtime) with regard to heali
ng rates, time until healing, symptom relief, and tolerability. A tota
l of 248 outpatients with benign gastric ulcer were included. Results:
The healing rates after 2, 4, and 8 weeks were 37%, 87%, and 97%, res
pectively, in the pantoprazole and 19%, 58%, and 80% in the ranitidine
group. The differences between the two groups were significant at 2 w
eeks (p < 0.01), 4 weeks (p < 0.001), and 8 weeks (p < 0.001; Cochran/
Mantel-Haenszel method). Ulcer healing proceeded significantly faster
with pantoprazole (p < 0.001; Uleman's U-test). Both treatments were w
ell tolerated. Conclusions: Pantoprazole appears to be superior to ran
itidine in gastric ulcer healing.