LONG-TERM STABILITY OF SODIUM MONOFLUOROPHOSPHATE

This paper reports data on the long term stability of the phosphorusfl uorine bond of sodium monofluorophosphate (MFP). Spontaneous hydrolysi s of the drug in bulk form follows first order kinetics. Chemical stab ility, expressed as its t(1/2), was found to differ with different MFP preparations (t(1/2) = 35 to 114 months). Chemical stability of MFP i n tablets appears dependent upon the method employed in their preparat ion. The long term stability of aqueous solutions is affected, as expe cted, by pH and temperature.