LIPOPEROXIDATION INDUCED BY HYDROGEN-PEROXIDE IN HUMAN ERYTHROCYTE-MEMBRANES .1. PROTECTIVE EFFECT OF GINKGO-BILOBA EXTRACT (EGB-761)

The antioxidant potential of Ginkgo biloba extract (EGb 761) on health y human erythrocyte membranes was investigated. Lipoperoxidation was i nduced in erythrocyte suspensions using hydrogen peroxide, in the pres ence of EGb 761 at 37 degrees C; malondialdehyde production was determ ined as the indicator of lipoperoxidation during the incubation period . The results for EGb 761 at concentrations of 0, 25, 50, 125, 250 and 500 mu g/ml suggest that the antioxidant potential of EGb 761 in eryt hrocyte membranes increases with dose. Similarly, using different incu bation periods (0, 15, 30, 45 or 60 min) indicated that the antioxidan t effect of EGb 761 increased by the incubation time,