CONSPICUOUS GROWTH OF INTRAVENOUSLY INOCULATED STAPHYLOCOCCUS-AUREUS IN SUBCUTANEOUSLY ESTABLISHED EHRLICH ASCITES TUMOR-TISSUE OF MICE

Intratumoral growth of Staphylococcus aureus was compared with the int rarenal growth, to examine the usefulness of the method as a marker of its pathogenicity. When 5 x 10(7) CFU/mouse of three derivatives from S. aureus Cowan I with different intrarenal growth were intravenously injected into Ehrlich tumor-bearing mice, they lodged in the tumor ti ssue at approximately 10(3) CFU/0.1g by 30 min after infection, and gr ew in the range of 10(6) CFU/0.1 g to 10(8) CFU/0.1 g by day 4, regard less of their intrarenal growth capacity. In contrast, S. saprophyticu s lodged in both tissues to the same degree as S. aureus, but did not grow at all. The time course of the staphylococcal growth was differen t between tumor tissue and kidney, suggesting differences in the local responses against S. aureus.